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KMID : 0361020060490090912
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Korean Journal of Otolaryngology - Head and Neck Surgery
2006 Volume.49 No. 9 p.912 ~ p.917
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Role of Mast Cells in a Aspergillus Murine Model of Allergic Rhinitis
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강준명/Kang JM
조진희/방충일/박찬순/신지현/이동호/이흥엽/Cho JH/Bang CI/Park CS/Shin JH/Lee DH/Lee HY
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Abstract
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Background & Objectives: Mast cells are the main effector cells in the immediate phase of the allergic responses. To evaluate the role of mast cells on the development of allergen-induced eosinophilic inflammation in a murine model of allergic rhinitis(AR), we compared the responses of mast cell deficient (W/Wv) mice with congenial normal (W/W+) mice.
Materials & Methods: Mice were sensitized intranasally with an extract of Aspergillus fumigatue (Af) for 3 weeks, and challenged intranasally with a single dose (acute model) or single dose every day for 5 consecutive days (chronic model). Interleukin (IL)-5 in nasal lavage fluids (NLF), histologic examination and Af-specific immunoglobulins (Ig) were examined in W/Wv mice and W/W+mice.
Results: In the sensitized W/Wv mice, the number of eosinophils in the nasal mucosa and IL-5 in NLF after repeated allergen challenge were not significantly different from those of W/W+ mice. In contrast, the number of eosinophils in the nasal mucosa and IL-5 in NLF after single allergen challenge were partially attenuated in W/Wv mice. The levels of Af-specific IgE and IgG1 in both acute and chronic models were not different between W/Wv mice and W/W+ mice.
Conclusion: These findings suggest that eosinophilic inflammation caused by repeated allergen challenge are independent of mast cells in this AR model.
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KEYWORD
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